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KMID : 1140120090140020140
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Cancer Prevention Research
2009 Volume.14 No. 2 p.140 ~ p.145
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Chlorella Vulgaris May Have Protective Effects on Bioelement Metabolism in Cadmium Exposed Rats
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Shim Jae-Young
Shin Hye-Seoung
Kim Byung-Gon
Han Jae-Gab
Ha Woel-Kyu
Om Ae-Son
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Abstract
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We investigated the effects of Chlorella vulgaris (CV) on cadmium (Cd) status and mineral (Zn, Cu, Fe, Ca and Mg) contents in Cd-administered rats for 8 weeks. Forty male rats (5 weeks old, n=10/group) were given control tap water or tap water containing 10 ppm of CdCl2 ad libitum. They were divided into a control group and 3 experimental groups consisting of a Cd (Cd/CV0%) group or a 5% of CV (Cd/CV5%) group or a 10% of CV (Cd/CV10%) group. The concentration of Cd, Ca, Fe, Mg, Cu and Zn in the serum, liver, kidney, spleen, urine and feces were measured by Inductively Coupled Plasma (ICP-MS). The results showed that body weight gain in a control and CV-treated groups were significantly higher than that in Cd/CV0% group. The relative liver and kidney weight are significantly decreased by CV treatments. Cd levels in liver and the kidney and feces were in dose-dependent manner. Cd level in CV-treated groups was decreased while Ca, Fe, Mg and Zn concentration was increased in liver and kidney. On the other hand, Cd was more excreted in CV-treated groups than in Cd/CV0% group. Thus, CV may have beneficial effects on excretion of Cd and retention of divalent metals.
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KEYWORD
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Chlorella vulgaris, Mineral, Cadmium
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